Selumetinib Intermediate
O-(2-(vinyloxy)ethyl)hydroxylamine
CAS: 391212-29-6
Molecular Formula: C4H9NO2
Selumetinib Intermediate - Names and Identifiers
Selumetinib Intermediate - Physico-chemical Properties
| Molecular Formula | C4H9NO2 |
| Molar Mass | 103.12 |
| Density | 0.972 |
| Boling Point | 60-65 °C(Press: 20 Torr) |
| pKa | 4.07±0.70(Predicted) |
| Storage Condition | -20℃ |
| Use | This product is for scientific research only and shall not be used for other purposes. |
Selumetinib Intermediate - Reference Information
| Application | 1-[2-(aminooxy) ethoxy] ethylene is an intermediate in organic synthesis and a pharmaceutical intermediate, can be used in laboratory research and development process and chemical and pharmaceutical synthesis process. |
| preparation | 1-[2-(aminooxy) ethoxy] ethylene was prepared as follows: step A:2-(2-(vinyloxy) ethoxy) isoindoline -1, 3-dione to 2-(vinyloxy) ethanol (20.4mL,227mmol), to a solution of triphenylphosphine (59.5g,227mmol) and N-hydroxyphthalimide (37.0g,227mmol) in THF(450mL) was added DEAD(35.9mL). About 227mmol at 0 °c under N2 atmosphere). After stirring at room temperature for 16 h, the reaction mixture was concentrated in vacuo. The residue was filtered, washed with chloroform, and the filtrate was concentrated in vacuo. The residue was purified by SiO2 column chromatography (Hexane: EtOAc = 2:1) to give 2-(2-(vinyloxy) ethoxy) isoindoline -1, 3-dione (32.5g,61.4%) as a yellow solid. To 2-(2-(vinyloxy) ethoxy) isoindoline -1, 3-dione (32.0g,137mmol) in DCM(96.0mL) to the above solution was added dropwise an aqueous solution of methylhydrazine (15.8mL,137mmol). Room temperature. After stirring for 1 hour at room temperature, The resulting suspension was diluted with diethyl ether and filtered. The filtrate was concentrated in vacuo. The residue was purified by column chromatography on SiO2 (Hexane: EtOAc = 3:2 to 1:1) to give O-(2-(vinyloxy) as a yellow oil ethyl)-hydroxylamine (10.7g,76%). |
Last Update：2024-04-09 02:00:13
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Product Name: O-(2-(vinyloxy)ethyl)hydroxylamine Visit Supplier Webpage Request for quotation
CAS: 391212-29-6
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CAS: 391212-29-6
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